Kojic Acid thiabKojic Acid Dipalmitateyog ob qho khoom xyaw tshuaj pleev ib ce uas tau siv dav rau lawv cov tawv nqaij - brightening thiab pigment - kho cov khoom. Lawv feem ntau piv vimkojic acid dipalmitateyog ib qho ruaj khov dua, roj -soluble derivative ntawm kojic acid, tsim los kov yeej qhov tsis txaus ntawm cov khoom qub. Ob yam tshuaj yog los ntawm kojic acid, uas yog ib txwm muab los ntawm fermentation khoom ntawm tej yam fungi, tshwj xeeb tshaj yog cov tsiaj koom nyob rau hauv fermentation ntawm mov thiab soy. Txawm li cas los xij, txawm tias lawv cov keeb kwm muaj feem cuam tshuam, lawv cov khoom siv tshuaj lom neeg, kev ruaj ntseg, kev ua tau zoo nyob rau hauv cov xwm txheej sib txawv, thiab cov kev cai tsim tawm txawv heev.
Los ntawm kev tshawb fawb txog kev kho kom zoo nkauj, cov kws tsim qauv feem ntau sib cav txog qhov twg yuav siv raws li cov khoom lag luam, lub hom phiaj kev lag luam, xav tau lub neej txee, kev sib raug zoo nrog lwm cov khoom siv, thiab kev ua siab ntev ntawm daim tawv nqaij. Nkag siab txog qhov zoo sib xws thiab qhov sib txawv ntawm ob tus neeg ua kom pom kev kaj lug no yog qhov tseem ceeb rau cov neeg tsim khoom lag luam, cov kws tshaj lij dermatology, thiab cov kws tshuaj ntsuam xyuas kev lag luam uas tsom mus xaiv cov khoom tsim nyog rau ib daim ntawv thov kom zoo nkauj. Kab lus no muab cov lus piav qhia txog kev tshawb fawb, nthuav dav, thiab cov lus piav qhia ntawm ob qho khoom xyaw los txhawb kev txiav txim siab tshaj lij- ua.
Kojic Acid yog dab tsi?
Kojic acid yog ib qho tshwm sim tshwm sim los ntawm cov txheej txheem metabolic ntawm ntau cov fungi, suav nrog Aspergillus oryzae. Nws tau siv dav hauv cov tshuaj pleev ib ce rau ntau xyoo vim nws muaj peev xwm inhibit melanin ntau lawm. Kojic acid ua haujlwm feem ntau los ntawm kev thaiv cov tyrosinase, qhov tseem ceeb enzyme koom nrog hauv kev sib txuas ntawm melanin los ntawm tyrosine. Thaum cov kev ua tyrosinase txo qis, daim tawv nqaij maj mam ua ntau dua -toned vim tias tsawg dua melanin pigments raug tsim.
Chemically, kojic acid yog hydrophilic (dej{0}}soluble) molecule. Nws solubility ua rau nws yooj yim rau kev koom ua ke rau hauv dej -raws li formulations xws li serums, lotions, thiab gels. Txawm li cas los xij, kojic acid tau zoo -cov ntaub ntawv nyuaj rau kev ruaj ntseg. Nws yog rhiab heev rau cua sov, lub teeb, oxygen, thiab pH hloov. Hauv ntau qhov xwm txheej, kojic acid tuaj yeem oxidize thiab darken nyob rau hauv formulations, nws thiaj li txo nws cov hauj lwm zoo. Qhov kev tsis sib haum xeeb no yog ib qho ntawm cov laj thawj tseem ceeb ntawm cov kws tshuaj pleev ib ce tshuaj pleev ib ce pib tsim cov khoom siv xws li kojic acid dipalmitate.
Tsis tas li ntawd, kojic acid tuaj yeem ua rau mob me me rau qee tus neeg, tshwj xeeb tshaj yog nyob rau ntau dua. Thaum nws yog cov khoom siv dav dav pom zoo, cov qauv tsim yuav tsum ua tib zoo sib npaug nrog cov khoom lag luam ruaj khov thiab ua haujlwm ntev.
Kojic Acid Dipalmitate yog dab tsi?
Kojic acid dipalmitate (KAD), tseem hu ua kojic dipalmitate, yog lipophilic (roj{0}}soluble) ester derivative ntawm kojic acid. Nws yog tsim los ntawm esterifying kojic acid nrog palmitic acid, uas ua rau ib tug ruaj khov molecule nrog txhim khu kev qha tiv thaiv oxidation, lub teeb raug, thiab kub variations.
Ib qho ntawm qhov zoo ntawm kojic acid dipalmitate yog nws qhov kev ruaj ntseg zoo dua. Tsis zoo li kojic acid-uas tuaj yeem hloov xim thaum lub sijhawm-KAD tuav nws txoj kev ncaj ncees ntev dua, muab cov qauv kev ntseeg siab rau lub sijhawm ntev - kev ua tau zoo ntawm cov khoom ci ci. Lwm qhov txiaj ntsig tseem ceeb yog nws cov roj solubility, uas tso cai rau nws yooj yim muab tso rau hauv cov roj-raws li formulations xws li cream, lotions, foundations, thiab emulsions uas muaj ib tug tseem ceeb roj theem.
Kojic acid dipalmitate yog suav tias yog softer dua kojic acid, ua rau nws haum rau rhiab tawv formulations. Txawm hais tias KAD tsis muaj zog dua kojic acid hauv nws daim ntawv nyoos vim nws yuav tsum tau hloov rov qab mus rau kojic acid dawb hauv daim tawv nqaij, nws qhov ruaj khov thiab kev sib raug zoo feem ntau ua rau muaj kev cuam tshuam ntev dua -.
Zuag qhia tag nrho, kojic acid dipalmitate yog ib qho kev txhim kho ntawm kojic acid, tsim los daws cov teeb meem tsis ruaj khov thiab khaus khaus cuam tshuam nrog cov khoom qub.
Qhov txawv ntawm Kojic Acid thiab Kojic Acid Dipalmitate
1) Chemical Structure thiab Solubility
Kojic acid yog dej -soluble.
Kojic acid dipalmitate yog roj- soluble vim esterification nrog palmitic acid.
Qhov sib txawv no cuam tshuam cov hom tshuaj pleev ib ce twg tuaj yeem sib xyaw ua ke txhua yam khoom.
2) Kev ruaj ntseg
Kojic acid yog rhiab heev rau cua sov, pH hloov, thiab oxidation, feem ntau tig xim av thiab poob hauj lwm zoo.
Kojic acid dipalmitate yog qhov ruaj khov thiab tiv taus oxidation, ua rau nws nyiam rau ntev - txee- cov khoom siv lub neej.
3) Cov tawv nqaij rhiab heev
Kojic acid tej zaum yuav ua rau khaus, tshwj xeeb tshaj yog nyob rau hauv cov tawv nqaij rhiab heev los yog thaum siv nyob rau hauv siab concentration.
KAD feem ntau yog me me, muab cov kev xaiv ntev dua rau kev siv sijhawm ntev -.
4) Kev ua tau zoo
Kojic acid muaj zog dua nyob rau hauv nws tam sim ntawd tyrosinase - inhibiting kev ua si.
KAD tsis tshua muaj zog tab sis muab kev ua haujlwm zoo ib yam nyob rau lub sijhawm vim muaj kev ruaj ntseg zoo dua.
Zoo sib xws ntawm Kojic Acid thiab Kojic Acid Dipalmitate
1) Keeb kwm
Ob leeg yog muab los ntawm kojic acid, fermentation los ntawm -cov khoom ntawm fungi siv hauv kev tsim khoom noj.
2) Lub Hom Phiaj Tseem Ceeb
Ob qho khoom xyaw tsom melanin tsim los ntawm kev cuam tshuam txoj hauv kev tyrosinase.
3) Kev siv hauv tshuaj pleev ib ce
Ob leeg yog siv hauv cov tshuaj pleev kom ci, tshuaj tiv thaiv - cov tshuaj pleev ib ce, kho tawv nqaij, thiab cov suab nrov- yav tsaus ntuj formulations.
4) Compatibility nrog rau lwm cov Brightening Agents
Ob leeg tuaj yeem ua ke nrog cov khoom xyaw xws li vitamin C derivatives, niacinamide, licorice extract, arbutin, thiab tranexamic acid los txhim kho tag nrho cov teeb pom kev zoo.
Yuav Ua Li Cas Xaiv Qhov Zoo?
1) Xaiv Kojic Acid Thaum:
- Koj xav tau kev ua kom muaj zog ci ntsa iab.
- Cov mis yog feem ntau yog dej-raws li.
- Cov khoom lag luam yog tsim los rau kev tshaj lij lossis luv luv - siv sijhawm (qhov teeb meem kev ruaj ntseg tsis tshua muaj teeb meem).
- Koj tab tom tsom rau cov neeg siv khoom paub txog kev ua haujlwm ntawm - qhov chaw muaj zog - kho cov khoom xyaw.
- Txawm li cas los xij, ua tib zoo xav txog qhov muaj peev xwm ua kom khaus thiab muaj kev pheej hmoo ntawm oxidation.
2) Xaiv Kojic Acid Dipalmitate Thaum:
- Koj yuav tsum tau ntev - cov khoom lag luam ruaj khov thiab kev ua haujlwm tau zoo.
- Cov formulation muaj ib tug tseem ceeb roj theem.
- Koj lub hom phiaj yog - cov neeg siv daim tawv nqaij los yog txhua hnub - siv cov khoom pleev xim.
- Koj xav tau cov khoom siv ci ntsa iab uas haum rau cov cream, tshuaj pleev thaiv hnub, lub hauv paus, thiab tshuaj pleev.
Xaus
Kojic acid thiab kojic acid dipalmitate sib koom cov hauv paus chiv keeb thiab cov hom phiaj zoo sib xws, tab sis lawv ua tau txawv vim qhov sib txawv ntawm cov qauv tshuaj, solubility, thiab stability. Kojic acid muaj kev ua tau zoo tam sim ntawd tab sis raug kev txom nyem los ntawm kev tsis ruaj khov thiab muaj peev xwm ua rau khaus.Kojic acid dipalmitate, ntawm qhov tod tes, muab qhov ruaj khov, roj-soluble, thiab softer lwm txoj kev uas nyiam nyob rau hauv ntev - txee- lub neej thiab rhiab heev - daim tawv nqaij formulations.
Kev xaiv ntawm ob yog nyob ntawm kev xav tau ntawm kev tsim, cov hom phiaj ntawm cov neeg siv khoom, hom khoom, thiab kev txiav txim siab txog kev tswj hwm. Ob qho tib si tseem muaj kev xaiv tseem ceeb hauv kev lag luam tshuaj pleev ib ce niaj hnub no, tso cai rau cov kws tsim qauv tsim kho cov kev daws teeb meem thoob plaws ntau hom tawv nqaij - daim ntawv thov ci.
Kev ceev faj thiab kev txiav txim siab tshwj xeeb
Kojic Acid
- Zam kom tsis txhob muaj kev tawm dag zog ntau hauv - ntawm cov khoom rau cov tawv nqaij rhiab heev.
- Yuav tsum muaj cov tshuaj antioxidants hauv cov qauv kom qeeb oxidation.
- Tej zaum yuav nce rhiab heev rau hnub ci; pom zoo tshuaj pleev thaiv hnub nyob rau hauv txhua hnub.
- pH yuav tsum tau ua tib zoo tswj kom muaj kev ruaj ntseg.
Kojic Acid Dipalmitate
- Yuav tsum tau cua sov kom yaj vim roj solubility.
- Ua haujlwm zoo tshaj plaws hauv emulsions nrog lub zog roj theem.
- Txawm hais tias maj mam, kev siv ntau dhau kuj tseem yuav ua rau muaj kev cuam tshuam tsis tshua muaj tshwm sim.
- Tsis haum rau cov qauv roj tsawg heev -.
- Cov neeg siv khoom sib txawv tuaj yeem xav tau siv raws li:
- Cov tawv nqaij rhiab heev: Kojic Acid Dipalmitate raug pom zoo.
- Cov tawv nqaij oily: Kojic acid nyob rau hauv ib lub teeb yuag dej -raws li serum ua hauj lwm zoo.
- Ntev - lub sij hawm brightening niaj hnub: KAD yog qhov zoo dua rau kev ruaj ntseg.
- Kev kho mob tshaj lij: High-purity kojic acid feem ntau yog siv.
Cov ntaub ntawv
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2. Burdock, GA, Soni, MG, & Carabin, IG (2001). Kev soj ntsuam kev nyab xeeb ntawm kojic acid. Khoom noj khoom haus thiab tshuaj toxicology.
3. Sarkar, R., et al. (2021). Depigmenting agents: Kev hloov tshiab. International Journal of Dermatology.
4. Draelos, ZD (2018). Cosmetic Dermatology: Cov khoom thiab cov txheej txheem. Wiley-Blackwell.
5. Rawlings, AV (2006). Hom tawv nqaij haiv neeg: Formulation le caag. Phau ntawv Journal of Dermatological Science.
6. Phau ntawv Journal of the Society of Cosmetic Chemists – Cov ntaub ntawv ntawm kojic acid derivatives stability thiab formulation cwj pwm.